Oral administration of CpG-ODNs suppresses antigen-induced asthma in mice
نویسندگان
چکیده
منابع مشابه
Immunotherapy of Chenopodium Album Induced Asthma by Intranasal Administration of CpG Oligodeoxynucleotides in BALB/c Mice
Background: There are many therapeutic methods for allergic conditions. CpG oli-gonucleotides play a critical role in immunity via the augmentation of Th1 and suppres-sion of Th2 responses. Objective: In the present study we aimed to estimate the effec-tiveness of intranasal administration of CpG ODN plus Chenopodium album allergen in allergic asthma compared with the administration of allergen...
متن کاملimmunotherapy of chenopodium album induced asthma by intranasal administration of cpg oligodeoxynucleotides in balb/c mice
background: there are many therapeutic methods for allergic conditions. cpg oli-gonucleotides play a critical role in immunity via the augmentation of th1 and suppres-sion of th2 responses. objective: in the present study we aimed to estimate the effec-tiveness of intranasal administration of cpg odn plus chenopodium album allergen in allergic asthma compared with the administration of allergen...
متن کاملImmunotherapy of Chenopodium album induced asthma by intranasal administration of CpG oligodeoxynucleotides in BALB/c mice.
BACKGROUND There are many therapeutic methods for allergic conditions. CpG oligonucleotides play a critical role in immunity via the augmentation of Th1 and suppression of Th2 responses. OBJECTIVE In the present study we aimed to estimate the effectiveness of intranasal administration of CpG ODN plus Chenopodium album allergen in allergic asthma compared with the administration of allergen al...
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Despite the widespread use of curcumin for centuries in Eastern medicine as an anti-inflammatory agent, its molecular actions and therapeutic viability have only recently been explored. While curcumin does have potential therapeutic efficacy, both solubility and bioavailability must be improved before it can be more successfully translated to clinical care. We have previously reported a novel f...
متن کاملco-administration of cpg oligonucleotides and chenopodium album extract reverse igg2a/igg1 ratios and increase ifn-gamma and il-10 productions in a murine model of asthma
asthma is a disorder of increasing severity and prevalence. recent knowledge about the pathogenesis of asthma emphasizes its inflammatory nature. cpg oligonucleotides are a class of compounds containing motifs based on the cytosine-guanine dinucleotides (cpg-odns). these motifs are suppressed in mammalian dna. they induce inflammation in mammals characterized by the induction of t helper type 1...
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ژورنال
عنوان ژورنال: Clinical and Experimental Immunology
سال: 2006
ISSN: 0009-9104,1365-2249
DOI: 10.1111/j.1365-2249.2005.03003.x